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Preparation of 14 C‐labelled 1,4‐dideoxy‐1,4‐imino‐D‐arabinitol: cyanosilylation of cyclic imines using KCN in a one‐pot synthesis
Author(s) -
Folkersen Birgitte M.,
Lundt Inge,
Foged Christian,
Valsborg Jacob S.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199912)42:12<1145::aid-jlcr268>3.0.co;2-y
Subject(s) - chemistry , aldimine , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
Abstract A new method for C‐C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI 2 . This method was used to prepare the potent α‐glucosidase inhibitor 1,4‐dideoxy‐1,4‐imino‐D‐arabinitol 14 C labelled at C‐5. Copyright © 1999 John Wiley & Sons, Ltd.