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Synthesis of deuterium labelled 4′‐hydroxydiclofenac
Author(s) -
Waterhouse Ian
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199911)42:11<1075::aid-jlcr263>3.0.co;2-a
Subject(s) - chemistry , metabolite , cytochrome p450 , deuterium , substrate (aquarium) , stereochemistry , biochemistry , enzyme , physics , oceanography , quantum mechanics , geology
Diclofenac is a potentially useful substrate for the study of drug‐drug interactions caused by modulation of the activity of specific isoforms of cytochrome P450. The synthesis of a deuterium labelled version of its principal human metabolite, 4′‐hydroxydiclofenac, for use as an internal standard in LC‐MS‐MS studies, is described. Copyright © 1999 John Wiley & Sons, Ltd.