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Synthesis of 7‐[ 123 I]iodotacrine: a potential SPECT agent to map acetylcholinesterase
Author(s) -
Akula Murthy R.,
Kabalka George W.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199910)42:10<959::aid-jlcr254>3.0.co;2-m
Subject(s) - tacrine , acetylcholinesterase , chemistry , acetylcholinesterase inhibitor , enzyme inhibitor , enzyme , cholinesterase , pharmacology , biochemistry , medicine
9‐Amino‐1,2,3,4‐tetrahydroacridine (Tacrine), a cognitive enhancer, is an inhibitor of the enzyme acetylcholinesterase. The synthesis of no‐carrier‐added 7‐[ 123 I]iodotacrine, was accomplished in four steps for potential use in mapping acetylcholinesterase. Copyright © 1999 John Wiley & Sons, Ltd.