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Synthesis of radiofluorinated O‐tyrosine and preliminary evaluation as possible aromatic amino acid decarboxylase tracer
Author(s) -
Dejesus Onofre T.,
Nickles R. Jerome,
Murali Dhanabalan
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199908)42:8<781::aid-jlcr238>3.0.co;2-a
Subject(s) - chemistry , aromatic l amino acid decarboxylase , tyrosine , tracer , in vitro , aromatic amino acids , specific activity , decarboxylase inhibitor , amino acid , stereochemistry , enzyme , biochemistry , physics , nuclear physics , medicine , levodopa , disease , pathology , parkinson's disease
[ 18 F]Fluoro‐o‐tyrosines (FOT) were prepared by the direct reaction of [ 18 F]acetylhypofluorite with L‐o‐tyrosine. Two isomers were formed in this reaction, 3‐FOT and 5‐FOT, with unoptimized decay‐corrected isolated radiochemical yields of about 11% and 8%, respectively. Results of preliminary in vitro evaluation found 5‐FOT to be the more promising isomer and suggest further evaluation of this compound as aromatic amino acid decarboxylase (AAAD) PET tracer should be undertaken. Copyright © 1999 John Wiley & Sons, Ltd.