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Nicotinamide‐substituted complexes as redox markers
Author(s) -
Rother A.,
Kniess T.,
Pütz M.,
Jungclas H.,
Spies H.,
Johannsen B.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199907)42:7<673::aid-jlcr229>3.0.co;2-e
Subject(s) - chemistry , pyridinium , sodium dithionite , moiety , redox , ligand (biochemistry) , cofactor , nuclear magnetic resonance spectroscopy , mass spectrometry , salt (chemistry) , combinatorial chemistry , medicinal chemistry , inorganic chemistry , stereochemistry , chromatography , organic chemistry , receptor , biochemistry , enzyme
For developing a dihydropyridine/pyridinium salt redox delivery system that could be useful for SPECT investigations by 99m Tc compounds the synthesis of a mixed‐ligand complex of the long‐lived isotope 99 Tc is described. The new compound bearing a pyridinium salt moiety was characterised by NMR‐spectrometry and X‐ray structure analysis. By reduction with sodium dithionite the corresponding 1,4‐dihydropyridine complex was prepared and the stability in buffer, tissue homogenates, blood plasma and cerebrospinal fluid was investigated by UV‐VIS spectrometry. Copyright © 1999 John Wiley & Sons, Ltd.