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Synthesis of labelled oxylipins: leukotriene A 4 and 8‐ epi ‐prostaglandin F 2α
Author(s) -
Shevchenko V. P.,
Nagaev I. Yu.,
Myasoedov N. F.,
Guy A.,
Durand T.,
Vidal A.,
Vidal JP.,
Rossi JC.,
Bezuglov V. V.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199907)42:7<663::aid-jlcr228>3.0.co;2-k
Subject(s) - chemistry , saponification , metabolite , prostaglandin d2 , leukotriene , selectivity , prostaglandin , organic chemistry , chromatography , catalysis , biochemistry , medicine , asthma
Abstract Tritiated leukotriene A 4 and 8‐ epi ‐prostaglandin F 2α methyl esters were prepared from the corresponding acetylenic precursors by selective reduction with tritium gas to provide a probe for the metabolite identification of these oxylipins. Partially deactivated Pd‐catalysts were prepared from commercial products and their composition was optimized to achieve the better selectivity. A micro‐method for the saponification of labelled oxylipins methyl esters was used. Copyright © 1999 John Wiley & Sons, Ltd.