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Polymer‐supported radiopharmaceuticals: [ 131 I]MIBG and [ 123 I]MIBG
Author(s) -
Hunter Duncan H.,
Zhu Xizhen
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199907)42:7<653::aid-jlcr227>3.0.co;2-q
Subject(s) - chemistry , cartridge , yield (engineering) , desorption , filtration (mathematics) , polymer , chromatography , radiochemistry , adsorption , organic chemistry , mechanical engineering , materials science , statistics , mathematics , engineering , metallurgy
A new method has been developed that produces no‐carrier‐added [ 131 I]MIBG in ≥90% radiochemical yield and high chemical purity. Isolation and purification are simple involving just filtration and absorption and desorption onto a C18 Sep‐Pak ™ cartridge. No‐carrier‐added material should avoid the potential pharmacological side effects accompanying the current method of production. Copyright © 1999 John Wiley & Sons, Ltd.