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Tri‐ n ‐octyl[ 32 P]phosphine oxide. synthesis and biodistribution via the hepatic artery of rats
Author(s) -
Fortineau AnneDominique,
Brichory Franck,
Pellen Pascal,
Sai Catherine,
Dazord Léontine,
Mortier Jacques,
Vaultier Michel,
Bourguet Patrick
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199906)42:6<527::aid-jlcr214>3.0.co;2-9
Subject(s) - chemistry , biodistribution , phosphine oxide , magnesium , ether , radiochemistry , chloride , kidney , medicine , phosphine , pharmacology , organic chemistry , biochemistry , in vitro , catalysis
The purpose of this study was to analyse the biodistribution of tri‐ n ‐octyl[ 32 P]phosphine oxide ([ 32 P]TOPO) in rats following intrahepatic arterial injection so as to assess its potential as a radiopharmaceutical for the treatment of hepatic tumours in humans. The retention of [ 32 P]TOPO remained high in liver and decreased rapidly in kidney, bone marrow and blood. The synthesis of [ 32 P]TOPO was performed in a one step procedure from [ 32 P]OCl 3 and n ‐octyl magnesium chloride in diethyl ether at 0°C. Copyright © 1999 John Wiley & Sons, Ltd.