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A high yielding synthesis of [5‐ 14 C]‐5H‐dibenzo[a,d]cyclohepten‐5‐one (dibenzosuberenone) using [ 14 C]‐dimethylformamide
Author(s) -
Kendall John T.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199905)42:5<477::aid-jlcr208>3.0.co;2-p
Subject(s) - chemistry , yield (engineering) , dimethylformamide , carboxylic acid , stereochemistry , organic chemistry , materials science , solvent , metallurgy
A seven step synthesis of dibenzosuberenone 1 is presented in which [ 14 C]‐DMF is used in lieu of 14 CO 2 to prepare the carboxylic acid intermediate 8 . The advantages of this procedure over other commonly used methods is discussed. The title compound was obtained at a specific activity of 53 mCi/mmol (61% overall radiochemical yield). Copyright © 1999 John Wiley & Sons, Ltd.