Premium
Synthesis of [9,10‐ 3 H]‐3‐azidosalicyl‐N‐(n‐octadecyl)amide
Author(s) -
Wu Dezhu,
Lu Bin,
Huang Wenlin,
Chen Shizhi,
Xu Jianxing
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199904)42:4<373::aid-jlcr198>3.0.co;2-s
Subject(s) - chemistry , amide , sodium azide , sodium nitrite , tritium , sodium , nitrite , medicinal chemistry , nuclear chemistry , stereochemistry , organic chemistry , physics , nuclear physics , nitrate
The synthesis of [9,10‐ 3 H]‐3‐azidosalicyl‐N‐(n‐octadecyl)amide, which can act as the molecular probe, was consisted of three step reaction. First 3‐nitrosalicyclic acid reacted with oleyleamine to form 3‐nitrosalicyl‐N‐(9′‐octadeceny)aminde, that reduced by tritium to the [9,10‐ 3 H]‐3‐amionsalicyl‐N‐(n‐octadecyl)amide. It then reacted with sodium nitrite and, sodium azide to synthesize [9,10‐ 3 H]‐3‐azidosalicyl‐N‐(n‐octadecyl)amide. Its specific activity and radiochemical purity were 46 Ci/mmol and >98% respectively. Copyright © 1999 John Wiley & Sons, Ltd.