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A route for the preparation of [ 32 P]‐sodium monofluorophosphate
Author(s) -
Wierczinski B.,
Kolar Z. I.,
Sedlick E. P.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199904)42:4<349::aid-jlcr196>3.0.co;2-0
Subject(s) - chemistry , phosphoric acid , yield (engineering) , salt (chemistry) , nuclear chemistry , inorganic chemistry , molar ratio , sodium , ammonium , organic chemistry , catalysis , materials science , metallurgy
[ 32 P]‐labelled sodium monofluorophosphate (Na 2 FPO 3 ) was prepared according to a procedure, which is based on melting of a mixture of carrier‐added [ 32 P]‐phosphoric acid and ammonium bifluoride, both solid. Monofluorophosphate was precipitated as the silver salt from the reaction mixture, then it was converted to the sodium salt by using a cation exchange column in Na + form. The influence of the molar ratios of the reactants, and the reaction time on the final yield was studied. Powder X‐ray diffraction showed a chemical purity of about 98% and absence of NaF in the final product. After a reaction time of 2 hours and a molar ratio of the reactants of 1 : 1, the yield for the reaction was 30% of the initial 32 P activity, corresponding to a specific activity of 56 MBq 32 P per mmol. An increase in yield is possible by increasing the reaction time, a higher specific activity may be obtained by a decrease of carrier phosphoric acid. The advantages of the procedure developed are the availability of [ 32 P]‐phosphoric acid, and the simple preparation of the compound. Copyright © 1999 John Wiley & Sons, Ltd.