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Synthesis and biodistribution of technetium‐99m‐labelled N ‐(diethylaminoethyl)benzamide via a bis(dithiocarbamate) nitridotechnetium(V) complex
Author(s) -
Auzeloux Philippe,
Papon Janine,
Masnada Thierry,
Borel Michèle,
Moreau MarieFrance,
Veyre Annie,
Pasqualini Roberto,
Madelmont JeanClaude
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199904)42:4<325::aid-jlcr193>3.0.co;2-j
Subject(s) - biodistribution , chemistry , benzamide , dithiocarbamate , ligand (biochemistry) , technetium , technetium 99m , stereochemistry , medicinal chemistry , combinatorial chemistry , nuclear chemistry , organic chemistry , nuclear medicine , biochemistry , receptor , scintigraphy , in vitro , medicine
N ‐(2‐diethylaminoethyl)‐4‐iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a 99m Tc analogue, we synthesized a sodium N ‐{2‐[4‐( N ‐diethylaminoethylcarbamoyl)phenyl]ethyl}‐ N ‐methyldithiocarbamate ligand in 7 steps from methyl 4‐(bromomethyl)benzoate. The corresponding nitridotechnetium complex formed by a ligand exchange method was purified and its biodistribution in mice bearing the B16 murine melanoma was determined. Copyright © 1999 John Wiley & Sons, Ltd.