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Preparation of 198 Au(I)‐labelled gold‐chloroquine complex [ 198 Au(PPh 3 )(CQ)]PF 6 as a potential antimalarial agent
Author(s) -
Dadachova E.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199903)42:3<287::aid-jlcr189>3.0.co;2-o
Subject(s) - chloroquine , chemistry , plasmodium falciparum , antimalarial agent , malaria , artemisinin , pharmacology , combinatorial chemistry , biology , immunology
198 Au(I)‐labelled gold‐chloroquine complex [ 198 Au(PPh 3 )(CQ)PF 6 has been prepared for the enhancement of antimalarial action against chloroquine‐resistant strains of Plasmodium falciparum of recently reported [Au(PPh 3 )(CQ)]PF 6 . [ 198 Au(PPh 3 )(CQ)]PF 6 was synthesized via 3‐step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep‐Pak® C18 cartridge. Specific activity of the complex was 1·5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine‐resistant malaria is discussed. Copyright © 1999 John Wiley & Sons, Ltd.