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Synthesis of 3β‐(4‐[ 125 I]iodophenyl)tropane‐2‐β‐pyrrolidine carboxamide ([ 125 I]RTI‐229)
Author(s) -
Zhong Desong,
Kotian Pravin,
Wyrick Christopher D.,
Seltzman Herbert H.,
Kepler John A.,
Kuhar Michael J.,
Boja John W.,
Carroll F. Ivy
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199903)42:3<281::aid-jlcr188>3.0.co;2-x
Subject(s) - tropane , chemistry , pyrrolidine , carboxamide , yield (engineering) , iodide , derivative (finance) , iodine 123 , sodium iodide , nuclear chemistry , stereochemistry , organic chemistry , nuclear medicine , medicine , materials science , economics , financial economics , metallurgy
A WIN 35,065‐2 analog, 3β‐(4‐iodophenyl)tropane‐2β‐pyrrolidine carboxamide (RTI‐229), has been radiolabelled with iodine‐125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier‐free sodium iodide‐125 as the isotope source. Purification by reversed‐phase HPLC gives [ 125 I]RTI‐229 in good yield (89·4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/μmol, 78·6 GBq/μmol, based on the specific activity of the Na 125 I used). Copyright © 1999 John Wiley & Sons, Ltd.