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Synthesis of [2‐ 14 C]perfluorohexane
Author(s) -
Haddach M.,
Sapienza J.,
Sharts C. M.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199903)42:3<227::aid-jlcr181>3.0.co;2-t
Subject(s) - chemistry , ethyl acetate , chemical synthesis , organic chemistry , combinatorial chemistry , biochemistry , in vitro
A general synthesis of [2‐ 14 C]perfluoroalkanes from 1‐iodoperfluoroalkanes and ethyl acetate was developed by synthesis of unlabeled perfluorodecane from 1‐iodoperfluorooctane. Using the general synthesis, [2‐ 14 C]perfluorohexane was synthesized from ethyl [1‐ 14 C]acetate and 1‐iodoperfluorobutane as illustrated in Scheme 1. Copyright © 1999 John Wiley & Sons, Ltd.