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Synthesis of [ 14 C]Azodicarbonamide
Author(s) -
HristovaKazmierski Maria K.,
Kepler John A.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199902)42:2<203::aid-jlcr183>3.0.co;2-0
Subject(s) - chemistry , hydrazine (antidepressant) , yield (engineering) , nuclear chemistry , radiochemistry , potassium , organic chemistry , chromatography , materials science , metallurgy
[ 14 C]Azodicarbonamide, a potent inhibitor of HIV‐1 and HIV‐2 was prepared by reaction of hydrazine sulfate with potassium [ 14 C]cyanate, followed by oxidation of the resulting biurea. The overall radiochemical yield was 57% and the specific activity of the product was 1.48 GBq/mmol (39.9 mCi/mmol). Copyright © 1999 John Wiley & Sons, Ltd.