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Synthesis of [ 14 C]Cerivastatin
Author(s) -
Radtke Martin,
Angerbauer Rolf
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199902)42:2<101::aid-jlcr171>3.0.co;2-a
Subject(s) - chemistry , yield (engineering) , phosphonate , aldehyde , bromide , derivative (finance) , convergent synthesis , alkene , combinatorial chemistry , carbon 14 , stereochemistry , side chain , organic chemistry , materials science , physics , quantum mechanics , economics , financial economics , metallurgy , catalysis , polymer
The title compound [ 14 C]Cerivastatin ([ 14 C]]BAY w 6228) was synthesized in order to introduce the label into the metabolically stable 7‐position of the side chain. Convergent synthesis was performed using a chiral aldehyde for alkene formation. Starting from [ 14 C]carbon dioxide and a suitable pyridine bromide the labelled phosphonate derivative was obtained in 5 steps. The synthesis was completed in 4 additional steps and the radiochemical yield amounted to 10%. Copyright © 1999 John Wiley & Sons, Ltd.