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Study of liver function tests using various stable isotope labelled compounds in liver cirrhosis
Author(s) -
Sakamoto Akio,
Nabeya Yoshihiro,
Isono Kaichi
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199901)42:1<93::aid-jlcr170>3.0.co;2-1
Subject(s) - breath test , cirrhosis , chemistry , gastroenterology , ammonium chloride , medicine , liver function tests , hepatic function , liver function , organic chemistry , helicobacter pylori
3 different stable isotope compounds which are metabolized in various sites of the liver were used to examine assessment methods which permit a precise expression of liver functions. The following 3 tests were performed in 17 cirrhotic patients and 16 healthy subjects as controls; 13 C‐tyrosine breath test, 15 N‐ammonium chloride oral loading test, 13 C‐aminopyrine breath test. The ratio of cirrhotic patients to controls was 89.0% (N.S.), 39.5% (p<0.001), 32.9% (p<0.001) in 13 C‐tyrosine breath test, 15 N‐ammonium chloride oral loading test, 13 C‐aminopyrine breath test respectively. In cirrhotic patients the microsome function was most severely damaged, which is expressed by the 13 C‐aminopyrine breath test. The result of the Student's t test of 13 C‐aminopyrine breath test was −9.722, which was higher than that of the 15 N‐ammonium chloride oral loading test, −5.033. Accordingly, it was recognized that the 13 C‐aminopyrine breath test most reflected a degree of disorder as a liver function test and also showed the highest reliability. Copyright © 1999 John Wiley & Sons, Ltd.