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A hydrazino nicotinamide derivative of cholesterol for radiolabelling liposomes with 99m Tc
Author(s) -
Judge Luke M.,
O'Leary Daniel J.,
Fujii Gary,
Skenes Craig,
Paquette Tom,
Proffitt Richard T.
Publication year - 1999
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199901)42:1<23::aid-jlcr163>3.0.co;2-e
Subject(s) - chemistry , liposome , labelling , derivative (finance) , cholesterol , yield (engineering) , nicotinamide , choline , hydrazine (antidepressant) , technetium , phosphatidyl choline , combinatorial chemistry , biochemistry , membrane , nuclear chemistry , enzyme , materials science , financial economics , economics , metallurgy , phospholipid
Liposomes were labelled with 99m Tc by a new method, via a nicotinyl hydrazine derivative of cholesterol ( 7 ). The synthesis of the technetium‐binding molecule was completed in 5 steps with an overall yield of 18%. Preliminary 99m Tc labelling studies indicate that 7 can be incorporated into distearoylphosphatidyl choline/cholesterol liposomes and retain technetium binding activity. Copyright © 1999 John Wiley & Sons, Ltd.