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Simple methods for the labelling of N‐methyl amines using isotopically labelled methyl iodide
Author(s) -
Fellows Ian,
Carr Richard M.,
deBoeck Nigel,
Montgomery Stephen,
Waterhouse Ian,
Sutherland Derek R.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199812)41:12<1127::aid-jlcr158>3.0.co;2-9
Subject(s) - chemistry , labelling , methyl iodide , iodide , amine gas treating , isotope dilution , isotopic labeling , organic chemistry , radiochemistry , chromatography , mass spectrometry , biochemistry
Methods for the synthesis of isotopically labelled N‐methyl amines using the target amine and isotopically labelled methyl iodide in a quaternisation/dequaternisation strategy are described. The method has been further refined to allow the synthesis of such amines without any isotopic dilution. Copyright © 1998 John Wiley & Sons, Ltd.