Premium
Preparation of [ 14 C]G2.5 and [ 14 C]G5.5 Starburst ® PAMAM dendrimers: the first example of dendrimer radiosynthesis
Author(s) -
Maxwell Brad D.,
Fujiwara Hideji,
HabibiGoudarzi Sohrab,
Ortiz Justin P.,
Logusch Sherry J.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998100)41:10<935::aid-jlcr146>3.0.co;2-s
Subject(s) - dendrimer , chemistry , radiosynthesis , methyl acrylate , radiochemistry , acrylate , organic chemistry , combinatorial chemistry , polymer chemistry , polymer , copolymer , microbiology and biotechnology , in vivo , biology
A procedure for preparing 14 C‐labelled half‐generation Starburst ® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with 14 C‐labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/ mmol in very high radiochemical purity.Copyright © 1998 John Wiley & Sons, Ltd.