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Synthesis of tritium‐labelled biologically active analogues of progesterone by selective hydrogenation of 16α,17α‐cyclohex‐3′‐en‐pregna‐1,4‐dien‐3,20‐dione
Author(s) -
Shevchenko V. P.,
Nagaev I. Yu.,
Potapova A. V.,
Myasoedov N. F.,
Kamernitsky A. V.,
Levina I. S.,
Kulikova L. E.,
Smirnov A. N.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998100)41:10<919::aid-jlcr150>3.0.co;2-a
Subject(s) - chemistry , tritium , hydrogen , molar ratio , radiochemistry , nuclear chemistry , steroid , biological activity , stereochemistry , organic chemistry , biochemistry , catalysis , in vitro , hormone , physics , nuclear physics
The procedure of selective hydrogenation with gaseous tritium of 16α,17α‐cyclohex‐3′‐en‐pregna‐1,4‐dien‐3,20‐dione ( St0 ) has been elaborated, and isotropically labelled 16α,17α‐cyclohexanopregna‐1,4‐dien‐3,20‐dione ( St1 ), 16α,17α‐cyclohex‐3′‐en‐pregna‐4‐en‐3,20‐dione ( St2 ), 16α,17α‐cyclohexanopregn‐4‐en‐3,20‐dione ( St3 ) with molar radioactivity of 41, 44, 85 Ci/ mmol, respectively, obtained. By hydrogenation with gaseous hydrogen, tritium labelled ( St3 ) was converted to 16α,17α‐cyclohexano‐5α‐pregnan‐3,20‐dione ( 5 α‐ St4 ) and 16α,17α‐cyclohexano‐5β‐pregnan‐3,20‐dione ( 5 β‐ St4 ).Copyright © 1998 John Wiley & Sons, Ltd.