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Synthesis and characterisation of a double deuterium‐labelled ferrochloroquine
Author(s) -
Biot Christophe,
Caron Sabine,
Maciejewski Lucien A.,
Brocard Jacques S.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998100)41:10<911::aid-jlcr145>3.0.co;2-4
Subject(s) - chemistry , deuterium , amine gas treating , double bond , stereochemistry , carbon 13 nmr , combinatorial chemistry , organic chemistry , physics , quantum mechanics
Starting from the well known precursor N , N ‐dimethyl(ferrocenylmethyl)amine, the total synthesis of double deuterium labelled ferrochloroquine, a ferrocenic compound mimicking chloroquine, is reported. The labelled drug 1 has been fully characterised by 1 H, 2 H, 13 C NMR and MS MALDI TOF experiments. Copyright © 1998 John Wiley & Sons, Ltd.