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Synthesis of [allyl‐2,3‐ 3 H]‐MN‐9201
Author(s) -
Wu Dezhu,
Huang Wenlin,
Wang Wen,
Mei Qibing
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998090)41:9<785::aid-jlcr133>3.0.co;2-d
Subject(s) - chemistry , tritium , methylene , antagonist , catalysis , medicinal chemistry , radiochemistry , organic chemistry , biochemistry , receptor , physics , nuclear physics
Key step of the synthesis of calcium antagonist MN‐9201 was the cyclizing addition of the allyl‐3‐amino‐crotonate onto methyl 2‐[(3‐nitrophenyl) methylene]‐3‐oxobutanoate. It was then used to synthesize [Allyl‐2,3‐ 3 H]‐MN‐9201 by the catalytic addition of tritium gas. Its radiochemical purity and specific activity were 98% and 2.1 TBq/mmol, respectively. © 1998 John Wiley & Sons, Ltd.