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Synthesis of high specific activity [1‐ 14 C] 3‐N,N‐dimethylaminopropylamine
Author(s) -
Jian Zhigang,
Filer Crist,
Kelly Terence P.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998080)41:8<781::aid-jlcr128>3.0.co;2-5
Subject(s) - chemistry , nitrile , yield (engineering) , cyanoacetamide , specific activity , medicinal chemistry , organic chemistry , enzyme , materials science , metallurgy
A convenient synthesis of high specific activity [1‐ 14 C] 3‐N,N‐dimethylaminopropylamine 10 is described. The reaction between [ 14 C]KCN and N,N‐dimethyl bromoacetamide 7 afforded [nitrile‐ 14 C] N,N‐dimethyl cyanoacetamide 8 . Stepwise reduction of 8 provided 99% pure 10 in 59% overall radiochemical yield. The specific activity was 53.3 mCi/mmol. © 1998 John Wiley & Sons, Ltd.