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Synthesis of a [ 99m Tc] pharmacomodulated Cyclam—a potential radiotracer functional brain imaging
Author(s) -
Borel Michele,
Moreau MarieFrance,
Veyre A.,
Madelmont JeanClaude
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(1998080)41:8<755::aid-jlcr124>3.0.co;2-m
Subject(s) - chemistry , cyclam , moiety , ether , alkoxy group , yield (engineering) , medicinal chemistry , aryl , alkyl , ethanol , organic chemistry , materials science , metal , metallurgy
Condensation of 2{4‐[2‐(diethylamino)ethoxy]phenyl}ethanol tosylate with a large excess of 1,4,8,11 tetraazacyclotetradecane (CYCLAM) in DMF gave N‐2‐{4‐[2‐(diethylamino)ethoxy]‐phenyl}‐ethyl‐1,4,8,11‐tetraazacyclotetradecane: 4 which was isolated and purified through its Cu‐complex. [ 99m Tc] 4 was prepared (80% yield–99% radiochemical purity) using a commercial sodium [ 99m Tc] pertechnetate generator. Compound 4 is made up of a nitrogen crown ether analog moiety allowing [ 99m Tc] labelling, mono N‐functionalized with an aryl‐alkyl ether group previously labelled with [ 125 I] and studied in detail. © 1998 John Wiley & Sons, Ltd.