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A model‐based isotopic analysis of O 2 transport during anemia and transfusion
Author(s) -
Heller Hartmut,
Göbel Bernd Otto,
Schuster KlausDieter
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199805)41:5<399::aid-jlcr93>3.0.co;2-i
Subject(s) - chemistry , hemoglobin , oxygen , anemia , oxygen transport , packed red blood cells , blood transfusion , surgery , medicine , biochemistry , organic chemistry
We studied the relative role of blood flow to limit oxygen (O 2 ) transport in patients suffering from chronic anemia and with respect to the transfusion of packed red cells. The stable isotopic oxygen molecules 16 O 2 and 16 O 18 O were used. 16 O 2 diffuses 3% faster and in addition passes the respiratory chain 1.3% more rapidly than 16 O 18 O, but within convective pathways it is transported as rapidly as 16 O 18 O. Thus, with increasing limitation by blood flow, the isotopic composition of oxygen changes less. By using a series resistance model we calculated the oxygen partial pressure difference between arterial and venous blood (PavO 2 ) on the basis of the change in 16 O 18 O/ 16 O 2 ratios. Nine patients suffering from chronic anemia as well as 14 normal volunteers were studied. In five patients transfusions had to be performed periodically. By means of respiratory mass spectrometry, 16 O 18 O/ 16 O 2 ratios were determined in expiratory gas mixtures. PavO 2 dropped more distinctly through transfusion (−13 mmHg