Premium
Synthesis of high specific activity [ 14 CO] methyl isocyanate and its use in the preparation of [ 14 CO] eserine, [ 14 CO] carbaryl and [ 14 CO] IPMU
Author(s) -
Poullain D.,
Noël J.P.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199805)41:5<387::aid-jlcr92>3.0.co;2-s
Subject(s) - chemistry , triethylamine , isocyanate , sodium azide , organic chemistry , polyurethane
The preparation of [ 14 CO] methyl isocyanate from [1‐ 14 C] acetyl chloride and activated sodium azide through the Curtius rearrangement was optimized (50% yield/[1‐ 14 C] sodium acetate‐ 50 mCi/mmol) and the reagent immediately used for the synthesis of [ 14 CO] eserine, [ 14 CO] carbaryl and [ 14 CO] IPMU. The condensation of methyl isocyanate with eseroline in the presence of triethylamine does not give rise to eserine but to the isomeric urea derivative 3 . © 1998 John Wiley & Sons, Ltd.