Premium
Non‐peptide fibrinogen receptor antagonists. 2 1 . The synthesis of [ 3 H]L‐738,167
Author(s) -
Hamill Terence G.,
Askew Ben C.,
Hartman George D.,
Claremon David A.,
McIntyre Charles J.,
Burns H. Donald
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199804)41:4<273::aid-jlcr76>3.0.co;2-1
Subject(s) - chemistry , peptide , receptor , fibrinogen , pharmacology , stereochemistry , biochemistry , medicine
The synthesis of [ 3 H]L‐738,167, an orally active fibrogen receptor antagonist, is described. A precursor containing the 2‐bromotolyl moiety was synthesized, and a reductive debromination reaction using tritium gas and Pearlman's catalyst gave the desired product with a final specific activity of 21 Ci/mmol. © 1998 John Wiley & Sons, Ltd.