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Electrophilic radioiodination of tyrosine derivatives
Author(s) -
K. Farah,
N. Farouk
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199804)41:4<255::aid-jlcr89>3.0.co;2-o
Subject(s) - chemistry , electrophile , chloramine t , oxidizing agent , tyrosine , labelling , radiochemistry , organic chemistry , catalysis , biochemistry
A comparative study on the electrophilic radioiodination of L‐tyrosine, L‐α‐methyl tyrosine and L‐tyrosine methyl ester has been carried out using chloramine‐T (CAT) and iodogen as oxidizing agents to generate electrophilic radioiodine. Optimization of the radioiodination conditions has been performed resulting in high labelling yields within short reaction times at room temperature. Radiochromatograms also revealed side product impurities at longer reaction time and higher oxidizing agent concentration. Maximum yields of 93%, 90% and 78% were obtained in case of CAT, while 87%, 88% and 53% were obtained in case of iodogen for L‐3‐[ 131 I] iodotyrosine, L‐3‐[ 131 I] iodo‐a‐methyl tyrosine and L‐3‐[ 131 I] iodotyrosine methyl ester respectively. © 1998 John Wiley & Sons, Ltd.