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Synthesis of N‐[2‐(2‐methylpropoxy)ethyl]‐N‐{2‐[(4‐methoxy) phenylmethylthio]phenyl}‐1‐pyrrolidineethanamine (E)‐2‐butenedioate (1:1) salt (CERM 12816): a potential anti‐anginal drug
Author(s) -
Mounetou Emmanuelle,
Poisson Claude,
Monteil André,
Madelmont JeanClaude
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199803)41:3<181::aid-jlcr68>3.0.co;2-8
Subject(s) - chemistry , bromide , yield (engineering) , salt (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , metallurgy , materials science
CERM 12816, which was required for metabolic studies, was labelled with [ 14 C] in the methylene carbon of the benzyl group. This involved eight steps starting from barium [ 14 C] carbonate and 4‐methoxyphenylmagnesium bromide, with a 20% overall yield. The specific activity was 208 MBq mmol −1 (5.6 mCi mmol −1 ). © 1998 John Wiley & Sons, Ltd.