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Synthesis of a new polyaminopolycarboxylic acid (BPHA) and its labeling with 99m Tc
Author(s) -
Liu Guozheng,
Liu Boli
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199802)41:2<97::aid-jlcr57>3.0.co;2-p
Subject(s) - chemistry , elemental analysis , salt (chemistry) , nuclear chemistry , radiochemistry , stereochemistry , inorganic chemistry , organic chemistry
N,N′–Bis(2–aminoethyl)propanediamine hexaacetic acid (BPHA) has been prepared as a tetrachloride salt. It has been characterized by 1 H NMR, Positive FAB MS, and elemental analysis. BPHA is easily labeled with 99m Tc in the pH range of 2–5 using SnCl 2 · 2H 2 O as reductant. The radioactive complex accumulates in both kidneys and liver and is fast excreted. © 1998 John Wiley & Sons, Ltd.