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Synthesis of DL‐α‐ 15 N‐tryptophan and 2‐ 15 N‐perlolyrine
Author(s) -
Tang Ganghua,
Wang Shinchen,
Wu Shuqin,
Jiang Guohui
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199802)41:2<139::aid-jlcr61>3.0.co;2-e
Subject(s) - chemistry , tryptophan , glycine , yield (engineering) , chloride , organic chemistry , amino acid , biochemistry , materials science , metallurgy
DL‐α‐ 15 N‐Tryptophan was synthesized by a simple and convenient chemical reduction method, starting from α‐ 15 N‐glycine and benzoyl chloride via five steps. The yield of DL‐α‐ 15 ‐N‐tryptophan from α‐ 15 N‐glycine was 46.9%. 2‐ 15 N‐Perlolyrine was synthesized from DL‐α‐ 15 N‐tryptophan and 5‐acetoxymethyl‐2‐formylfuran via three steps. The yield of 2‐ 15 N‐perlolyrine from DL‐α‐ 15 N‐tryptophan was 15.5%. © 1998 John Wiley & Sons, Ltd.