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Synthesis of 2‐amino‐5‐(1‐methyl‐5‐nitro‐[4‐ 3 H]‐2‐imidazolyl)‐1,3,4‐thiadiazole
Author(s) -
Chauviere G.,
Rousseau B.,
Pillon F.,
Perie J.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199801)41:1<47::aid-jlcr52>3.0.co;2-c
Subject(s) - chemistry , nitro , tetrahydrofuran , imidazole , nitro compound , tritiated water , medicinal chemistry , stereochemistry , tritium , organic chemistry , solvent , alkyl , physics , nuclear physics
Abstract 2‐Amino‐5‐(1‐methyl‐5‐nitro‐4‐iodo‐2‐imidazoyl)‐1,3,4‐thiadiazole ( 5 ) was prepared from imidazole via a 4‐steps sequence. Reductive desiodination of 5 using a tetrahydrofuran solution of NaBH 4 in the presence of tritiated water provided the title compound (specific radioactivity 12.6 Ci/mmol) in one step. © 1998 John Wiley & Sons, Ltd.