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Synthesis of carbon–14 labeled fluvastatin (Lescol®)
Author(s) -
Tang Y. S.,
Jones Lawrence,
Sunay Ustun B.
Publication year - 1998
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199801)41:1<1::aid-jlc52>3.0.co;2-b
Subject(s) - chemistry , yield (engineering) , indole test , ring (chemistry) , chloride , salt (chemistry) , sodium salt , stereochemistry , carbon 14 , fluvastatin , organic chemistry , pharmacology , inorganic chemistry , medicine , materials science , physics , quantum mechanics , metallurgy , simvastatin
[R*, S*]–(±)–7–[3–(4–Fluorophenyl)–1–(1–methylethyl)–1 H –indol–2–yl–3– 114 C]–3, 5– dihydrox –6–heptenoic acid, sodium salt (fluvastin, 4 ) was prepared from [ 14 C] bromoacetyl chloride in a six step synthesis with an overall radiochemical yield of 13.2%. This synthetic route was chosen because it puts the label in the metabolically stable 3– position of the indole ring. © 1998 John Wiley & Sons, Ltd.