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Synthesis of [ 3 H 2 ]‐21‐diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor
Author(s) -
Fagart Jérôme,
Sobrio Franck,
Marquet Andrée
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199710)39:10<791::aid-jlcr25>3.0.co;2-x
Subject(s) - labelling , chemistry , reagent , tritium , photoaffinity labeling , homogeneous , affinity label , combinatorial chemistry , catalysis , diazirine , receptor , stereochemistry , organic chemistry , biochemistry , physics , nuclear physics , thermodynamics
[ 3 H 2 ]‐21‐Diazoprogesterone ([ 3 H]21DP), a potent photoaffinity labelling reagent, has been synthesized in four steps from progesterone. Tritium has been introduced by homogeneous tritiation with Wilkinson's catalyst. © 1997 John Wiley & Sons, Ltd.