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Synthesis of tritiated 1‐octadecyl‐phosphothiolyl‐ myo ‐[1‐ 3 H]‐inositol. A new inhibitor of phosphatidylinositol‐specific phospholipase‐C
Author(s) -
Angelini G.,
Margonelli A.,
Ragni P.,
Sparapani C.,
Cellai L.,
Iannelli M. A.,
Cesta M. C.,
Lappa S.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199709)39:9<747::aid-jlcr16>3.0.co;2-f
Subject(s) - chemistry , phosphatidylinositol , tritium , phospholipase c , inositol , second messenger system , derivative (finance) , pi , enzyme , intracellular , biochemistry , phospholipase , stereochemistry , signal transduction , receptor , physics , nuclear physics , financial economics , economics
The title myo ‐[1‐ 3 H]‐Inositol derivative was synthesized and characterized by tritium‐N.M.R. The unlabelled compound proved a potent inhibitor of the cellular key enzyme phosphatidylinositol‐specific phospholipase‐C (PI‐PLC) involved in the production of intracellular second messengers and its tritium derivative was necessary in order to fully understand the mechanism of inhibition. © 1997 John Wiley & Sons, Ltd.