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Synthesis of a novel antiinflammatory agent, BTS 71321, singly labelled with carbon‐14 in two positions
Author(s) -
Baker Maurice W.,
Mewse Michael V.,
Shutler Stephen W.,
Taylor Lucyna M.,
Titman Roger B.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199708)39:8<685::aid-jlcr12>3.0.co;2-#
Subject(s) - chemistry , carbon fibers , combinatorial chemistry , stereochemistry , radiochemistry , composite material , composite number , materials science
The synthesis of the antiinflammatory compound, BTS 71321, singly labelled with carbon‐14 in two positions, is described. Labelling of the imidazole ring of the compound was achieved using [2‐ 14 C]imidazole, prepared from potassium [ 14 C]cyanide via potassium [ 14 C]thiocyanate, whereas labelling of the tertiary carbon atom in the chain was effected by means of procedure starting from barium [ 14 C]carbonate and involving an organocerium reagent. © John Wiley & Sons, Ltd.