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Synthesis, characterization and biodistribution of new 99m Tc nitrido complexes with derivatives of alkyl xanthates
Author(s) -
He Jiang,
Wu Yonghui,
Wang Xiangyun,
Liu Yuanfang
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199708)39:8<645::aid-jlcr6>3.0.co;2-#
Subject(s) - chemistry , xanthate , partition coefficient , dithiocarbamate , alkyl , biodistribution , ligand (biochemistry) , medicinal chemistry , ion exchange , stereochemistry , inorganic chemistry , ion , organic chemistry , receptor , biochemistry , in vitro
We have synthesized a series of neutral 99m Tc alkyl xanthates complexes with the [Tc ≡ N] + core, in which the xanthate ligand substituents are varied from pure alkyls to aminoalkyls (R 1 R 2 NR–). Analyses by TLC, ion exchange, partition coefficient (PC) determination and paper chromatography show that the complexes are neutral and lipid soluble. The 99m Tc complexes of dialkylaminoxanthates have a higher myocardial uptake than their counterparts of unsubstituted xanthate, but still lower that that of the [ 99m Tc ≡ N] 2+ complexes of dithiocarbamate. © John Wiley & Sons, Ltd.