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Catalytic effect of copper(II) chloride on the radioiodination of L‐p‐iodophenylalanine
Author(s) -
ElWetery A. S.,
ElMohty A. A.,
Ayyoub S.,
Raieh M.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199708)39:8<631::aid-jlcr8>3.0.co;2-0
Subject(s) - chemistry , copper , catalysis , yield (engineering) , solvent , acetamide , chloride , pivalic acid , inorganic chemistry , dimethyl sulfoxide , nuclear chemistry , formamide , medicinal chemistry , organic chemistry , materials science , metallurgy
The various iodophenylalanine isomers have been used for pancreatic imaging studies. In this work a convenient method was developed for incorporating radioactive iodine onto L‐p‐iodophenylalanine (p‐IPA) using copper(II) chloride to promote radioiodination. Radioiodination conditions were optimized in terms of reaction time, temperature, copper(II) chloride and p‐IPA concentration. Catalytic effect of other metal salts such as MgCl 2 ,6H 2 0, Ni(NO 3 ).6H 2 O, also pivalic acid and acetamide as a molten solvent were tested. Radioiodination of p‐IPA with NA 131 I in organic media such as dimethyl sulfoxide(DMSO) dimethyl formamide(DMF) and Dioxane were achieved and a comparison was made as to the labelling rates. The rate order was found to be as follows: Dioxane > DMSO > DMF The results showed that copper(II) chloride was effective for facilitating the exchange reaction with maximum yield (∼87%) after 60 min at 150°C. Activation energy of 13.3 kcal/mol was also determined. © John Wiley & Sons, Ltd.