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Synthesis of meta ‐iodobenzyl [ 11 C]guanidine
Author(s) -
Westerberg Göran,
Långström Bengt
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199706)39:6<525::aid-jlcr998>3.0.co;2-9
Subject(s) - chemistry , cyanogen bromide , guanidine , yield (engineering) , bromide , radiochemistry , nuclear chemistry , medicinal chemistry , organic chemistry , biochemistry , materials science , metallurgy , peptide sequence , gene
An efficient and fully automated one‐pot method for the synthesis of 3‐iodobenzyl [ 11 C]guanidine ([ 11 C]MIBG) was developed. Starting from [ 11 C]cyanogen bromide, [ 11 C]MIBG was obtained in 62 % radiochemical yield and a radiochemical purity higher than 98 % via the intermediate 3‐iodobenzyl [ 11 C]cyana/μmol (130 GBq/μmol) at the end of synthesis. © 1997 John Wiley & Sons, Ltd.