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Synthesis of a radiolabelled retinoid X receptor (RXR) specific ligand
Author(s) -
Held Pierre,
Heck MariePierre,
Iyer Jaya,
Gronemeyer Hinrich,
Lebeau Luc,
Mioskowski Charles
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199706)39:6<501::aid-jlcr995>3.0.co;2-s
Subject(s) - chemistry , retinoid , moiety , retinoid x receptor , ligand (biochemistry) , benzoic acid , stereochemistry , nuclear receptor , receptor , retinoid x receptor alpha , chemical synthesis , retinoid x receptor beta , combinatorial chemistry , retinoic acid , biochemistry , in vitro , transcription factor , gene
Synthesis of 4‐[2‐(5,5,8,8‐tetramethyl‐5,6,7,8‐tetrahydro‐naphthalen‐2‐yl)‐[1,3]dioxolan‐2‐yl]‐benzoic acid or SR11237, a specific ligand of Retinoid X Receptors, is described in a 3 H‐labelled version. The labelled retinoid was prepared in 5 steps and tritium was introduced through a final reduction of an aromatic dihalide moiety with 3 H 2 . © 1997 John Wiley & Sons, Ltd.