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The synthesis of [ 3 H]KW‐2189, a novel active antitumor antibiotic
Author(s) -
Nagamura Satoro,
Kinugawa Masahiko,
Ogasa Takehiro,
Saito Hiromitsu
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199706)39:6<471::aid-jlcr991>3.0.co;2-k
Subject(s) - chemistry , methyl iodide , iodide , antibiotics , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry
The synthesis of [ 3 H]KW‐2189, 2 , a novel active antitumor antibiotic, is described. The key intermediate, 6 , in the synthesis, was synthesized in four steps from duocarmycin B2 ( 1 ). Treatment of 6 with [ 3 H]methyl iodide in the presence of NaHCO 3 in MeOH‐Me 2 CO (1:1) afforded the [ 3 H]KW‐2189 with highly specific activity of 86.4 Ci/mmol. © 1997 John Wiley & Sons, Ltd.