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Synthesis of tritium labelled phosphonate analogues of sphinganine‐1‐phosphate
Author(s) -
Schick Andreas,
Schwarzmann Günter,
Kolter Thomas,
Sandhoff Konrad
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199705)39:5<441::aid-jlcr988>3.0.co;2-d
Subject(s) - phosphonate , chemistry , tritium , phosphate , radiochemistry , catalysis , sodium hydride , chemical synthesis , tritium illumination , organic chemistry , stereochemistry , biochemistry , physics , nuclear physics , in vitro
Tritiated phosphonate analogues 9 and 10 are prepared as analogues of sphinganine‐1‐phosphate 4 . The key step in this synthesis is the catalytic tritiation of the triple bond in reduction of the protected diethyl‐3‐(S)‐tert.‐butoxycarbonylamino‐4‐hydroxy‐5‐tridecinyl‐1‐phosphonate by means of sodium boro[ 3 H]hydride as tritium source. These compounds are synthesized to study their metabolic stability and to evaluate their biological properties. © 1997 John Wiley & Sons, Ltd.