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Synthesis of (R) and (S) 14 C‐labelled ethyl nipecotate, for preparation of GABA uptake ligands
Author(s) -
Valsborg Jacob S.,
Foged Christian
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199705)39:5<401::aid-jlcr986>3.0.co;2-v
Subject(s) - chemistry , yield (engineering) , enantiomer , specific activity , pyridine , high performance liquid chromatography , carboxylate , chromatography , radiochemistry , nuclear chemistry , organic chemistry , enzyme , materials science , metallurgy
14 C‐labelled (R)‐ and (S)‐ethyl 3‐[carboxyl‐ 14 C]piperidinecarboxylate were synthesised in 3 steps, including a chiral HPLC separation, starting from 3‐[carboxyl‐ 14 C]pyridine‐carboxylate. The overall radiochemical yield of the labelled (R)‐ and (S)‐enantiomers were 67% and 61%. The radiochemical purities were higher than 98% with specific radioactivities of 48 mCi/mmol. © 1997 John Wiley & Sons, Ltd.