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Synthesis of [2,3‐ 3 H]‐n‐butyl alcohol
Author(s) -
Huang Dezhu Wu Wenlin,
Wang Wen
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199704)39:4<349::aid-jlcr979>3.0.co;2-8
Subject(s) - chemistry , alcohol , crotonaldehyde , aluminum hydride , catalysis , lithium (medication) , primary alcohol , tert butyl alcohol , tritium , hydride , radiochemistry , allyl alcohol , organic chemistry , medicinal chemistry , nuclear chemistry , hydrogen , medicine , physics , nuclear physics , endocrinology , methoxide
Synthesis of [2,3‐ 3 H]‐n‐butyl alcohol consisted of two steps: crotonaldehyde was reduced with lithium aluminum hydride to crotyl alcohol, which with the catalytic addition of tritium gas was transformed to [2,3‐ 3 H]‐n‐butyl alcohol. Its specific activity and radiochemical purity were 29 TBq/g and 99%, respectively. © 1997 John Wiley & Sons, Ltd.