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Synthesis of a tritium‐labelled diether analog of phosphatidylinositol 4,5‐bisphosphate
Author(s) -
Chen Jian,
Prestwich Glenn D.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199703)39:3<251::aid-jlcr964>3.0.co;2-y
Subject(s) - tritium , chemistry , phosphatidylinositol , tritium illumination , inositol , chemical synthesis , radiochemistry , stereochemistry , biochemistry , in vitro , nuclear physics , physics , receptor , kinase
The synthesis of 1‐(1,2‐ O ‐diundecyl‐ sn ‐glycerylphosphoryl) 4,5‐D‐ myo ‐inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically‐pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP 2 and tritiation gave the high‐specific activity, tritium‐labelled analog. © 1997 John Wiley & Sons, Ltd.