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Preparation of carbon‐14 labeled N‐(2,6‐dichloro‐3‐methylphenyl)‐5,7‐dimethoxy[1,2,4]triazolo[1,5‐a]pyrimidine‐2‐sulfonamide
Author(s) -
McKendry L. H.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199703)39:3<231::aid-jlcr965>3.0.co;2-0
Subject(s) - chemistry , sulfonamide , pyrimidine , yield (engineering) , sulfonyl , combinatorial chemistry , chloride , process (computing) , carbon fibers , organic chemistry , stereochemistry , algorithm , materials science , alkyl , computer science , metallurgy , operating system , composite number
A new 6‐step process was developed for the synthesis of radiolabeled metosulam, a broadleaf post emergent herbicide being commercialized by DowElanco for use in small grains. Each step of the process can be accomplished in >80% yield thereby making the process a convenient and efficient route for the preparation of both radiolabeled and unlabeled samples of metosulam. A significant improvement was made in the coupling of the silylaniline with the sulfonyl chloride over the previously reported procedure which represents a key step in the process. © 1997 John Wiley & Sons, Ltd.