Premium
Synthesis of N,N ‐didemethylzolpidem‐ N ‐{2‐{3‐(4‐hydroxy‐3‐[ 125 I] iodophenyl)}methyl propionate} for use in radioimmunoassay
Author(s) -
De Clerck I.,
Daenens P.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199703)39:3<195::aid-jlcr958>3.0.co;2-8
Subject(s) - chemistry , zolpidem , radioimmunoassay , conjugate , chromatography , derivative (finance) , high performance liquid chromatography , pharmacology , biochemistry , medicine , mathematical analysis , mathematics , financial economics , economics , insomnia
The 125 I‐derivative of zolpidem was prepared by iodination of a L‐tyrosine methyl ester conjugate of a zolpidem precursor. The iodinated compound has been used as a tracer molecule in the development of a radioimmunoassay for zolpidem. It was purified by normal phase HPLC, in combination with gamma counting detection. The structure was confirmed by high resolution L‐SIMS. © 1997 John Wiley & Sons, Ltd.