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Synthesis of the monosodium salt of carbon‐14 labeled paclitaxel (Taxol®) 2′‐ethyl carbonate 7‐phosphonooxymethyl ether, a potential prodrug of paclitaxel
Author(s) -
Dischino Douglas D.,
Chen Shu Hui,
Golik Jerzy,
Walker Donald W.,
Wong Henry S. L.
Publication year - 1997
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199702)39:2<173::aid-jlcr956>3.0.co;2-q
Subject(s) - chemistry , paclitaxel , prodrug , ether , salt (chemistry) , carbonate , organic chemistry , nuclear chemistry , biochemistry , cancer , medicine
The monosodium salt of Carbon‐14 labeled paclitaxel (Taxol®) [N3′‐ 14 COPh] 2′‐ethyl carbonate 7‐phosphonooxymethyl ether, was prepared from C‐14 labeled paclitaxel [N3′‐ 14 COPh] in 5 steps. The radiochemical purity of the final product was greater than 99% and the specific activity was 25 μCi/mg. © 1997 John Wiley & Sons, Ltd.